UNDERSTANDING AL

AL amyloidosis is a rare disease that begins when abnormal plasma cells in the bone marrow produce proteins called light chains. These proteins can misfold and form amyloid deposits, potentially affecting the heart, kidneys, nerves, digestive system, liver, and other tissues.

Symptoms vary and may include fatigue, shortness of breath, swelling, dizziness, numbness, digestive changes, unexplained weight loss, or changes in kidney function. Diagnosis usually involves blood and urine tests, a tissue biopsy, amyloid typing, and tests to determine which organs are affected.

Treatment is personalized and focuses on stopping the production of harmful light chains while protecting affected organs. Options may include chemotherapy, immunotherapy, supportive care, and, for selected patients, a stem cell transplant. Blood markers may improve before organ symptoms, so recovery can take time.

AL amyloidosis is serious, but treatments continue to advance. Early diagnosis, accurate amyloid typing, and care from an experienced, coordinated medical team can help patients understand their options and move forward with greater confidence.

This information is educational and does not replace guidance from your healthcare team.

— HELP FOR THE ROAD AHEAD

This website and downloadable documents provide general education and support—not medical advice.